Description

Cyclohexanecarbonitrile, 2-Fluoro-1-Hydroxy-2-Methyl- (9Ci) is a high-value, fluorinated nitrile building block with a unique stereogenic center, making it a critical intermediate for advanced chemical synthesis. Its molecular structure, featuring both a hydroxyl and a fluorine substituent on the cyclohexane ring, provides versatile reactivity for constructing complex pharmacophores and agrochemicals. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to introduce fluorinated motifs and chiral complexity into their target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated organic compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Asymmetric Catalysis & Ligand Development: Employed as a starting material for synthesizing chiral ligands and catalysts used in enantioselective reactions.
• Fine Chemical & Flavor/Fragrance Intermediate: Utilized in the multi-step synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	Cyclohexanecarbonitrile, 2-Fluoro-1-Hydroxy-2-Methyl- (9Ci)
CAS No.	412034-84-5
Molecular Formula	C8H12FNO
Molecular Weight	157.19 g/mol
Synonyms	2-Fluoro-1-hydroxy-2-methylcyclohexanecarbonitrile; (1R,2S)-2-Fluoro-1-hydroxy-2-methylcyclohexanecarbonitrile (enantiomer); (1S,2R)-2-Fluoro-1-hydroxy-2-methylcyclohexanecarbonitrile (enantiomer); 2-Fluoro-2-methyl-1-hydroxycyclohexanecarbonitrile; trans-2-Fluoro-1-hydroxy-2-methylcyclohexanecarbonitrile; Fluoromethylhydroxycyclohexanecarbonitrile; Cyclohexanecarbonitrile, 2-fluoro-1-hydroxy-2-methyl-
EINECS	Contact for details

Quality Control

Our Cyclohexanecarbonitrile, 2-Fluoro-1-Hydroxy-2-Methyl- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee (specify isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.