Description

4'-Trifluoromethoxy-Biphenyl-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a biphenyl core substituted with a carboxylic acid and a trifluoromethoxy group. This molecular architecture is critical for imparting enhanced metabolic stability and bioavailability in active pharmaceutical ingredients (APIs). It is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical sectors for the synthesis of novel therapeutic agents and crop protection products.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and fungicides, where the trifluoromethoxy group contributes to improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials and liquid crystals due to its rigid biphenyl structure and fluorine content.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	4'-Trifluoromethoxy-Biphenyl-2-Carboxylic Acid
CAS No.	408366-18-7
Molecular Formula	C14H9F3O3
Molecular Weight	282.22 g/mol
Synonyms	[2'-(Trifluoromethoxy)[1,1'-biphenyl]-2-carboxylic acid; 2-(4-Trifluoromethoxyphenyl)benzoic acid; 4'-Trifluoromethoxy-2-biphenylcarboxylic Acid; Biphenyl-2-carboxylic acid, 4'-(trifluoromethoxy)-; 2-Carboxy-4'-trifluoromethoxybiphenyl]
EINECS	Contact for details

Quality Control

Every batch of 4'-Trifluoromethoxy-Biphenyl-2-Carboxylic Acid is manufactured under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, NMR, and MS, to ensure compliance with industry standards and customer-specific requirements. Certificates of Analysis (COA) documenting purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.