Description

2-Bromo-1-(2-(difluoromethoxy)phenyl)ethanone is a specialized brominated aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in its bifunctional reactivity, where the bromoacetyl group serves as a versatile electrophile for nucleophilic substitution, and the difluoromethoxy-substituted aromatic ring provides unique electronic and steric properties. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders or possessing anti-inflammatory properties.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Ligand and Catalyst Synthesis: Serves as a building block for creating sophisticated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Precursor: Employed in the synthesis of specialty polymers and advanced organic electronic materials due to its aromatic and halogenated structure.
• Chemical Biology Probe Development: Utilized to create covalent inhibitors or affinity probes for target identification and validation in drug discovery.

Basic Information

Product Name	2-Bromo-1-(2-(difluoromethoxy)phenyl)ethanone
CAS No.	405921-09-7
Molecular Formula	C9H7BrF2O2
Molecular Weight	265.05 g/mol
Synonyms	2-Bromo-1-[2-(difluoromethoxy)phenyl]ethanone; 2-Bromo-1-(2-(difluoromethoxy)phenyl)ethan-1-one; 2'-Bromo-2-(difluoromethoxy)acetophenone; α-Bromo-2-(difluoromethoxy)acetophenone; 405921-09-7; Ethanone, 2-bromo-1-[2-(difluoromethoxy)phenyl]-
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-(2-(difluoromethoxy)phenyl)ethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP principles and compliance with REACH regulations ensures a reliable supply for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.