Description

(3R)-(-)-3-(1-Methyl-1H-Indol-3-Yl)-1-Butyraldehyde is a chiral, non-racemic aldehyde derivative of 1-methylindole, serving as a sophisticated building block in asymmetric synthesis. This compound matters for its role as a key chiral intermediate in the production of high-value pharmaceuticals and complex organic molecules, enabling precise stereochemical control. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries engaged in developing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of potential drug candidates, particularly in central nervous system (CNS) and oncology research.
• Asymmetric Synthesis: Used as a chiral aldehyde component in stereoselective reactions such as aldol condensations and reductive aminations.
• Agrochemical Development: Serves as a building block for creating novel, chiral active ingredients with enhanced efficacy and selectivity.
• Fine Chemical Manufacturing: Employed in the production of specialty chemicals, flavors, fragrances, and advanced materials requiring specific stereochemistry.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and catalysis studies.
• Ligand and Catalyst Synthesis: Used to construct complex chiral ligands for asymmetric catalysis and metal-organic frameworks.

Basic Information

Product Name	(3R)-(-)-3-(1-Methyl-1H-Indol-3-Yl)-1-Butyraldehyde
CAS No.	405873-05-4
Molecular Formula	C₁₃H₁₅NO
Molecular Weight	201.27 g/mol
Synonyms	(3R)-3-(1-Methyl-1H-indol-3-yl)butanal; (R)-3-(1-Methyl-1H-indol-3-yl)butyraldehyde; (-)-3-(1-Methylindol-3-yl)butanal; (3R)-3-(1-Methylindol-3-yl)butanal; 405873-05-4; (R)-(-)-3-(1-Methyl-1H-indol-3-yl)butanal; 1-Butyraldehyde, 3-(1-methyl-1H-indol-3-yl)-, (3R)-
EINECS	Contact for details

Quality Control

Our (3R)-(-)-3-(1-Methyl-1H-Indol-3-Yl)-1-Butyraldehyde is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting standards for research and development use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This material is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.