Description

3-Butyn-2-One,4-(4-Fluorophenyl)-(9Ci) is a specialized fluorinated acetylenic ketone building block of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring both a fluorinated aromatic ring and a reactive alkyne-ketone system, makes it a valuable precursor for constructing complex heterocycles and functionalized intermediates. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Research: Used in the development of novel herbicides and fungicides, where the fluorine atom can enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for advanced polymers and functional materials with specific optical or electronic properties.
• Click Chemistry Substrate: The alkyne functionality makes it suitable for Huisgen cycloaddition reactions, a cornerstone of bioconjugation and combinatorial chemistry.
• Ligand Synthesis: Employed in the preparation of complex fluorinated ligands for catalysis and metal-organic frameworks (MOFs).
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological studies and the exploration of new chemical spaces.

Basic Information

Product Name	3-Butyn-2-One,4-(4-Fluorophenyl)-(9Ci)
CAS No.	405065-66-9
Molecular Formula	C10H7FO
Molecular Weight	162.16 g/mol
Synonyms	4-(4-Fluorophenyl)-3-butyn-2-one; 1-(4-Fluorophenyl)-3-butyn-2-one; 4-(4-Fluorophenyl)but-3-yn-2-one; 3-Butyn-2-one, 4-(4-fluorophenyl)-; 4-(p-Fluorophenyl)-3-butyn-2-one; 4-(4-Fluorophenyl)-2-butyn-4-one; (4-Fluorophenyl)ethynyl methyl ketone
EINECS	Contact for details

Quality Control

We supply 3-Butyn-2-One,4-(4-Fluorophenyl)-(9Ci) in high-purity grades suitable for research and process development. Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles—typically assessed via HPLC, GC, NMR, and IR spectroscopy—is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.