Description

1-Chloro-4-((chlorodifluoromethyl)sulfonyl)benzene is a specialized organosulfur compound featuring a chlorodifluoromethylsulfonyl functional group. This high-value intermediate is critical for introducing the unique sulfonyl fluoride moiety into target molecules, enabling advanced synthesis in demanding fields. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing sulfonamide-based drug candidates, particularly in protease inhibitor and kinase inhibitor research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the sulfonyl group contributes to biological activity and selectivity.
• Chemical Biology Probe Development: Serves as a reactive handle in SuFEx (Sulfur(VI) Fluoride Exchange) click chemistry for labeling proteins and constructing bioconjugates.
• Material Science: Intermediate for creating specialty polymers and surface modifiers with specific chemical resistance or surface energy properties.
• Ligand and Catalyst Preparation: Used to synthesize novel ligands for catalysis or metal-organic frameworks (MOFs).

Basic Information

Product Name	1-Chloro-4-((chlorodifluoromethyl)sulfonyl)benzene
CAS No.	403496-62-8
Molecular Formula	C7H3Cl2F2O2S
Molecular Weight	274.06 g/mol
Synonyms	4-Chloro-α,α-difluoro-α-(chlorosulfonyl)toluene; 1-Chloro-4-(chlorodifluoromethanesulfonyl)benzene; p-Chloro(chlorodifluoromethanesulfonyl)benzene; 4-Chlorophenyl chlorodifluoromethyl sulfone; Benzene, 1-chloro-4-[(chlorodifluoromethyl)sulfonyl]-; (4-Chlorophenyl)(chlorodifluoromethyl)sulfone
EINECS	Contact for details

Quality Control

Our production of 1-Chloro-4-((chlorodifluoromethyl)sulfonyl)benzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your synthetic workflows. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.