Description

1-(3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy)Propyl)Piperidine is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic targets.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those requiring complex biaryl linkages.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a versatile boron-containing coupling partner for palladium-catalyzed carbon-carbon bond formation with aryl halides or triflates.
• Medicinal Chemistry Research: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to optimize lead compounds.
• Ligand and Catalyst Development: Potential precursor for creating novel ligands or catalysts used in asymmetric synthesis.
• Material Science Research: Can be employed in the synthesis of organic electronic materials or polymers where specific aromatic architectures are needed.

Basic Information

Product Name	1-(3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy)Propyl)Piperidine
CAS No.	401895-68-9
Molecular Formula	C20H32BNO3
Molecular Weight	345.29 g/mol
Synonyms	1-[3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]propyl]piperidine; 4-(3-Piperidin-1-ylpropoxy)phenylboronic acid pinacol ester; 2-[4-[3-(1-Piperidyl)propoxy]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 401895-68-9; Piperidine, 1-[3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]propyl]-; Boronic acid, B-[4-[3-(1-piperidinyl)propoxy]phenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 1-(3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy)Propyl)Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.