Description

4'-(Pentafluorosulfur)Acetophenone is a high-purity fluorinated aromatic ketone building block, distinguished by its unique pentafluorosulfur (SF5) functional group. This compound matters for its role in advanced material science and pharmaceutical research, where the SF5 group is prized for imparting exceptional thermal stability, chemical inertness, and lipophilicity to target molecules. It is primarily needed by R&D chemists and process development scientists in the agrochemical, pharmaceutical, and specialty polymer industries for synthesizing novel active ingredients and high-performance materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS and anti-inflammatory pathways.
• Agrochemical Research: Used in the synthesis of next-generation herbicides and pesticides, where the SF5 group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing components in electronic display and lighting technologies.
• Polymer & Resin Modification: Incorporated to create specialty polymers with improved solvent resistance, thermal properties, and dielectric characteristics.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic additions, and other transformations to introduce the SF5 moiety into complex molecular architectures.
• Advanced Material Science: Used in the development of coatings, adhesives, and composites requiring high performance under extreme conditions.

Basic Information

Product Name	4'-(Pentafluorosulfur)Acetophenone
CAS No.	401892-83-9
Molecular Formula	C8H5F5OS
Molecular Weight	244.18 g/mol
Synonyms	1-[4-(Pentafluoro-λ6-sulfanyl)phenyl]ethan-1-one; 4-SF5-Acetophenone; p-SF5-Acetophenone; 4-(Pentafluorosulfanyl)acetophenone; 4-Acetylphenylsulfur pentafluoride; 4-Acetylbenzenesulfur pentafluoride; Ethanone, 1-[4-(pentafluoro-λ6-sulfanyl)phenyl]-; 4-(SF5)Acetophenone
EINECS	Contact for details

Quality Control

Our 4'-(Pentafluorosulfur)Acetophenone is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems support development and cGMP production for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.