Description

2,2-Difluoropropionamide is a high-value fluorinated organic building block essential for advanced chemical synthesis. This compound matters for its role in introducing the difluoromethyl group, a key moiety that can significantly alter the metabolic stability, lipophilicity, and bioavailability of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by fine chemical manufacturers producing specialized intermediates.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting metabolic diseases and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro moiety enhances biological activity and environmental persistence.
• Fluorinated Material Precursor: Serves as a starting material for synthesizing specialty fluorinated polymers, surfactants, and liquid crystals with unique surface properties and stability.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to improve the pharmacokinetic profiles of drug candidates.
• Custom Synthesis & Contract Manufacturing: A key reagent for fine chemical companies offering bespoke synthesis services for complex, fluorinated target molecules.
• Bioconjugation & Probe Development: Useful in the development of biochemical probes and diagnostic agents where fluorine atoms are used as tags or to modulate reactivity.

Basic Information

Product Name	2,2-Difluoropropionamide
CAS No.	49781-48-8
Molecular Formula	C3H5F2NO
Molecular Weight	109.07 g/mol
Synonyms	2,2-Difluoropropanamide; α,α-Difluoropropionamide; Propionamide, 2,2-difluoro-; 2,2-Difluoropropionic acid amide; DFPA; NSC 403714
EINECS	Contact for details

Quality Control

Our 2,2-Difluoropropionamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, and we support customer audits and regulatory documentation requests.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is hygroscopic (moisture-sensitive); ensure containers are kept tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.