Description

Megalomycin A 4'-o-Acetate is a chemically modified derivative of the macrolide antibiotic megalomycin A, where an acetate group is introduced at the 4'-hydroxyl position. This semi-synthetic modification is crucial for enhancing the compound's stability, bioavailability, and pharmacological profile for advanced research applications. It is primarily sought by pharmaceutical R&D and biotechnology sectors for the development of novel antibacterial agents and for in-depth structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for quality control and analytical method development in antibiotic production.
• Antibacterial Research: Used as a key intermediate or lead compound in the discovery and synthesis of new macrolide antibiotics with improved efficacy.
• Biochemical Studies: Employed in microbiological and enzymatic assays to study mechanisms of bacterial protein synthesis inhibition.
• Structure-Activity Relationship (SAR) Analysis: Essential for medicinal chemistry programs aiming to optimize the biological activity and pharmacokinetic properties of megalomycin derivatives.
• Academic & Institutional Research: Utilized in university and government laboratories for fundamental research in organic chemistry and microbiology.

Basic Information

Product Name	Megalomycin A 4'-o-Acetate
CAS No.	49669-75-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	4'-O-Acetyl-megalomycin A; Megalomycin A 4'-acetate; 4'-Acetoxy-megalomycin A; Antibiotic XK 62-2 acetate derivative; (2R,3S,4R,5S,6R,8R,10R,11R,12S,13S)-5-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,9,11,12,13-hexahydroxy-3,5,6,8,10,12-hexamethyl-1-oxacyclotetradecane-13,14-dione 4'-acetate
EINECS	Contact for details

Quality Control

Our Megalomycin A 4'-o-Acetate is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the product to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.