Description

1-Pyrrolyl-Borane, 1M Sol In Thf is a specialized organoboron reagent supplied as a 1.0 M solution in anhydrous tetrahydrofuran. This compound is a valuable building block in modern synthetic chemistry, offering a reactive source of the 1-pyrrolyl-boryl group for cross-coupling and functionalization reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex nitrogen-containing heterocycles. The pre-dissolved format ensures consistent reactivity and simplifies handling in air- and moisture-sensitive applications.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: As a key boron reagent for the synthesis of pyrrole-substituted biaryl and heteroaryl compounds.
• Pharmaceutical Intermediate Synthesis: For the introduction of the pyrrole moiety into drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Research: In the development of novel herbicides, fungicides, and insecticides containing pyrrole heterocycles.
• Material Science & Organic Electronics: As a precursor for conductive polymers, organic light-emitting diodes (OLEDs), and other electronic materials.
• Catalyst & Ligand Development: For the preparation of novel nitrogen-donor ligands used in homogeneous catalysis.
• Academic & Process R&D: Enabling methodological development and scalable synthesis routes in research laboratories.

Basic Information

Product Name	1-Pyrrolyl-Borane, 1M Sol In Thf
CAS No.	45376-40-7
Molecular Formula	C4H6BN
Molecular Weight	78.91 g/mol
Synonyms	1-Pyrrolylborane; Pyrrol-1-ylborane; 1H-Pyrrol-1-ylborane; Borane, pyrrol-1-yl-; 1-Pyrrolylboron; N-Pyrrolylborane; Pyrrolylborane; 1-Boranyl-1H-pyrrole
EINECS	Contact for details

Quality Control

Our 1-Pyrrolyl-Borane solution is manufactured under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is analyzed to confirm concentration, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing assay results, solvent content, and moisture levels is provided with every shipment. Our quality management system supports compliance with cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. The solution is highly volatile, easily oxidized, and moisture-sensitive. Keep away from heat, sparks, and open flame. Use only in a well-ventilated fume hood with appropriate personal protective equipment.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration (in THF)	1.0 M ± 0.05 M
Assay (NMR)	≥ 95.0%
Identification (IR)	Conforms to structure
Water Content (Karl Fischer)	≤ 0.05%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.