Description

Trimethyloxonium is a highly reactive methylating agent, widely recognized for its powerful electrophilic properties. Its primary value lies in its ability to efficiently transfer a methyl group to a variety of nucleophiles, including oxygen, nitrogen, and sulfur atoms, under relatively mild conditions. This makes it an indispensable reagent for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for the synthesis of complex molecules and fine chemicals where precise methylation is critical.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for O- and N-methylation in the production of active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Manufacturing: Used in the synthesis of herbicides, pesticides, and plant growth regulators requiring specific methylated structures.
• Material Science Research: Employed in the surface modification of polymers and the synthesis of specialized ionic liquids and catalysts.
• Organic Synthesis & Methodology Development: A staple electrophile in academic and industrial labs for constructing methyl ethers, esters, and ammonium salts.
• Biochemistry & Proteomics: Utilized as a chemical probe for studying protein structure and function through selective methylation.
• Fine Chemical Production: Applied in the manufacture of dyes, fragrances, and other specialty chemicals where controlled methylation is essential.

Basic Information

Product Name	Trimethyloxonium
CAS No.	43625-65-6
Molecular Formula	C₃H₉O⁺ (commonly as a salt, e.g., tetrafluoroborate BF₄⁻)
Molecular Weight	61.10 g/mol (for the cation)
Synonyms	Trimethyloxonium ion; Trimethyloxonium cation; Oxonium, trimethyl-; Trimethyloxonium salt; Me₃O⁺; TMO; Trimethoxyoxonium
EINECS	Contact for details

Quality Control

Our Trimethyloxonium products are manufactured under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and titration methods, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases and nucleophiles.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (NMR)	Conforms to structure
Assay (Titration)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.