Description

4-Fluorophenyl Chlorothionoformate is a specialized organosulfur reagent featuring both a chlorothionoformate group and a fluorinated aromatic ring. This unique structure makes it a valuable building block for the synthesis of thiocarbonates, thiocarbamates, and other sulfur-containing compounds in advanced chemical research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for introducing thiocarbonate or dithiocarbonate functionalities into active pharmaceutical ingredients (APIs) and prodrugs.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and insecticides that require fluorinated phenyl groups for enhanced bioactivity and environmental stability.
• Polymer Chemistry: Serves as a monomer or chain-transfer agent in the synthesis of specialty polymers and functional materials with tailored properties.
• Ligand and Catalyst Development: Employed to prepare sulfur-based ligands for transition metal catalysis and organocatalysis.
• Chemical Biology Probes: Useful for modifying peptides, proteins, and other biomolecules to study biological processes or create bioconjugates.
• Organic Synthesis Reagent: Acts as an electrophilic thionation agent for alcohols and amines, facilitating the preparation of various thiocarbonyl derivatives.

Basic Information

Product Name	4-Fluorophenyl Chlorothionoformate
CAS No.	42908-73-6
Molecular Formula	C7H4ClFOS
Molecular Weight	190.62 g/mol
Synonyms	4-Fluorophenyl chlorothioformate; p-Fluorophenyl chlorothionoformate; Chlorothionoic acid O-(4-fluorophenyl) ester; Carbonochloridothioic acid O-(4-fluorophenyl) ester; 4-Fluorophenyl chloromethanethioate; 4-Fluorophenoxythiocarbonyl chloride
EINECS	Contact for details

Quality Control

Our 4-Fluorophenyl Chlorothionoformate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.