Description

14-Deoxy-11,12-Didehydroandrographolide is a key diterpenoid lactone derivative, recognized for its significant biological activity and role as a primary active metabolite of andrographolide. This compound is essential for pharmaceutical research and development, particularly in the study of anti-inflammatory and immunomodulatory pathways. It is primarily sought by research institutions, pharmaceutical companies, and manufacturers of high-purity botanical reference standards and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediates: Serves as a critical building block in the synthesis of novel anti-inflammatory and antiviral drug candidates.
• Reference Standards: Used as a certified reference material (CRM) for quality control and analytical method development in herbal extract and pharmaceutical analysis.
• Biochemical Research: A vital tool for in-vitro and in-vivo studies investigating NF-κB signaling pathways, cytokine production, and other mechanisms of immune response.
• Natural Product Chemistry: Employed as a starting material for the semi-synthesis of more potent andrographolide analogs.
• Dietary Supplement R&D: Utilized in the development and standardization of advanced herbal formulations targeting immune support.

Basic Information

Product Name	14-Deoxy-11,12-Didehydroandrographolide
CAS No.	42895-58-9
Molecular Formula	C₂₀H₂₈O₄
Molecular Weight	332.44 g/mol
Synonyms	14-Deoxy-δ¹¹,¹²-Andrographolide; 14-Deoxy-11,12-Dehydroandrographolide; 3-[2-[Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone; Neoandrographolide (Note: often a related compound, but sometimes used interchangeably in literature); Andrographolide derivative 1; DDAG; 14-DDA
EINECS	Contact for details

Quality Control

Our 14-Deoxy-11,12-Didehydroandrographolide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with detailed chromatographic data and full traceability. Our quality commitment aligns with the standards required for pharmaceutical research and reference material applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive and easily oxidized; prolonged exposure to air and light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.