Description

14-Deoxy-11-Oxoandrographolide is a key diterpenoid lactone derivative, recognized for its significant biological activity and role as a primary metabolite of andrographolide. This compound is valued for its potent anti-inflammatory and hepatoprotective properties, making it a crucial intermediate and reference standard in advanced pharmaceutical research and development. It is primarily sought by manufacturers and research institutions in the pharmaceutical, nutraceutical, and phytochemical sectors for drug discovery, quality control, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of novel anti-inflammatory and hepatoprotective drug candidates.
• Reference Standard: Used as a high-purity analytical standard in HPLC and LC-MS for the quality control of herbal extracts and finished products containing Andrographis paniculata.
• Biochemical Research: Employed in in-vitro and in-vivo studies to investigate mechanisms of action related to NF-κB pathway inhibition and other anti-inflammatory targets.
• Nutraceutical Formulation: Incorporated into advanced dietary supplements aimed at supporting immune function and liver health.
• Active Pharmaceutical Ingredient (API) Development: Investigated for direct use or further derivatization in the development of new API molecules.

Basic Information

Product Name	14-Deoxy-11-Oxoandrographolide
CAS No.	42895-57-8
Molecular Formula	C₂₀H₂₈O₅
Molecular Weight	348.44 g/mol
Synonyms	14-Deoxy-11-oxoandrographolide; 3-[2-[Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone; 11-Oxo-14-deoxyandrographolide; Andrographolide derivative 11-oxo-14-deoxy; Neoandrographolide related compound
EINECS	Contact for details

Quality Control

Our 14-Deoxy-11-Oxoandrographolide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and MS, to ensure it meets high-grade standards suitable for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.