Description

2-Iodo-4-Methylbenzonitrile is a versatile halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. This compound is valued for its dual functional groups, which allow for selective cross-coupling reactions and further functionalization, making it a critical intermediate for research and development. It is primarily sought after by pharmaceutical, agrochemical, and material science industries for constructing complex molecules, including active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in constructing heterocyclic cores and functionalized aromatic systems.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the iodine atom facilitates efficient coupling to create diverse bioactive molecules.
• Material Science Research: Serves as a monomer or building block for creating specialized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions such as Suzuki, Sonogashira, and Heck couplings to form complex biaryl structures.
• Ligand and Catalyst Development: Utilized in the preparation of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development and exploring new synthetic pathways.

Basic Information

Product Name	2-Iodo-4-Methylbenzonitrile
CAS No.	42872-78-6
Molecular Formula	C8H6IN
Molecular Weight	243.05 g/mol
Synonyms	4-Methyl-2-iodobenzonitrile; 2-Iodo-p-tolunitrile; 2-Iodo-4-methylbenzenecarbonitrile; Benzonitrile, 2-iodo-4-methyl-; 2-Iodo-4-tolunitrile; 2-Cyano-5-iodotoluene; 4-Methyl-2-iodobenzene carbonitrile; 2-Iodo-4-methyl-benzonitrile
EINECS	Contact for details

Quality Control

Our 2-Iodo-4-Methylbenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to meet the stringent requirements of our global clientele in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.