Description

trans-1,2-Cyclooctanediol CAS NO 42565-22-0 is a high-purity, versatile chiral diol building block essential for advanced organic synthesis. Its rigid, eight-membered ring structure with defined stereochemistry makes it a valuable intermediate for constructing complex molecules with specific spatial orientations. This compound is particularly sought after by research and development teams in the pharmaceutical and fine chemical industries for applications in asymmetric synthesis, chiral ligand development, and the creation of novel macrocyclic compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of active pharmaceutical ingredients (APIs), particularly in asymmetric synthesis.
• Chiral Ligand & Catalyst Precursor: Used to develop novel ligands for transition metal catalysis, enabling stereoselective chemical transformations.
• Macrocycle & Host-Guest Chemistry: Serves as a building block for synthesizing crown ether analogs, cryptands, and other macrocyclic receptors due to its conformational constraints.
• Polymer Science: Employed as a monomer or chain extender to introduce rigidity and specific stereochemistry into specialty polymers and resins.
• Material Science Research: Utilized in the development of advanced organic materials, liquid crystals, and molecular machines.
• Academic & Industrial R&D: A fundamental tool for methodological studies in organic chemistry and the exploration of new synthetic pathways.

Basic Information

Product Name	trans-1,2-Cyclooctanediol
CAS No.	42565-22-0
Molecular Formula	C8H16O2
Molecular Weight	144.21 g/mol
Synonyms	(1R,2R)-Cyclooctane-1,2-diol; (1R,2R)-1,2-Cyclooctanediol; trans-(±)-1,2-Cyclooctanediol; rac-trans-1,2-Cyclooctanediol; Cyclooctane-1,2-diol, trans-; 1,2-Cyclooctanediol, (1R,2R)-rel-; (±)-trans-1,2-Cyclooctanediol
EINECS	Contact for details

Quality Control

Our trans-1,2-Cyclooctanediol is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral assay, NMR for structural confirmation, and Karl Fischer titration for moisture content. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de (trans isomer)
Melting Point	95 - 105 °C
Water Content (KF)	≤ 1.0 %
Residue on Ignition	≤ 0.1 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.