Description

2,2,2-Trifluoro-1-[2-(Trifluoromethyl)Phenyl]Ethan-1-One, also known as 2-(Trifluoroacetyl)Benzotrifluoride, is a high-value, multi-fluorinated aromatic ketone building block prized for its unique electronic and steric properties. This compound is essential for introducing the trifluoroacetyl and benzotrifluoride motifs, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring fluorinated compounds for enhanced bioavailability and target engagement.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the introduction of fluorine atoms improves environmental persistence and efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated polymers, liquid crystals, and organic electronic materials to alter dielectric properties and chemical resistance.
• Fine Chemical and Dye Intermediate: Utilized in the preparation of complex fluorinated dyes and specialty fine chemicals.

Basic Information

Product Name	2,2,2-Trifluoro-1-[2-(Trifluoromethyl)Phenyl]Ethan-1-One
CAS No.	42452-42-6
Molecular Formula	C9H4F6O
Molecular Weight	242.12 g/mol
Synonyms	2-(Trifluoroacetyl)Benzotrifluoride; α,α,α-Trifluoro-2'-(trifluoromethyl)acetophenone; 1-[2-(Trifluoromethyl)phenyl]-2,2,2-trifluoroethanone; 2-(Trifluoromethyl)phenyl Trifluoromethyl Ketone; o-(Trifluoromethyl)phenyl Trifluoromethyl Ketone; Benzotrifluoride, 2-(trifluoroacetyl)-; 2-Trifluoromethyl-α,α,α-trifluoroacetophenone
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-[2-(Trifluoromethyl)Phenyl]Ethan-1-One is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including chromatography and spectroscopy, to ensure high purity and consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.