Description

3'-Fluoro-4'-Methylacetophenone is a high-purity fluorinated aromatic ketone building block essential for advanced organic synthesis. This compound is valued for its role in introducing both fluorine and methyl-substituted phenyl groups into target molecules, enabling precise modulation of their physical, chemical, and biological properties. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality raw materials for complex synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds where fluorine substitution is used to enhance metabolic stability, bioavailability, and receptor binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorinated aromatic moiety can improve efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the development of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs), contributing to improved performance and stability.
• Chemical Research & Development: An important reagent in academic and industrial R&D labs for exploring new reaction pathways, creating novel fluorinated compounds, and developing catalytic processes.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fine chemicals, flavors, and fragrances that require specific aromatic ketone functionalities.

Basic Information

Product Name	3'-Fluoro-4'-Methylacetophenone
CAS No.	42444-14-4
Molecular Formula	C9H9FO
Molecular Weight	152.17 g/mol
Synonyms	1-(3-Fluoro-4-methylphenyl)ethanone; 3-Fluoro-4-methylacetophenone; 3-Fluoro-p-methylacetophenone; 3'-Fluoro-4'-methylacetophenone; 4'-Methyl-3'-fluoroacetophenone; 1-Acetyl-3-fluoro-4-methylbenzene; Ethanone, 1-(3-fluoro-4-methylphenyl)-
EINECS	Contact for details

Quality Control

Our 3'-Fluoro-4'-Methylacetophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.