Description

n-Me-Thr(Tbu)-Oh CAS NO 42417-72-1 is a protected amino acid derivative, specifically N-Methyl-O-tert-butyl-L-threonine, serving as a critical chiral building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates to construct complex peptide-based molecules with precise stereochemistry. It is primarily utilized by the pharmaceutical, biotechnology, and advanced materials sectors for applications in drug discovery, peptide therapeutics, and specialty chemical production.

Application

• Peptide Synthesis: A key intermediate in Solid-Phase Peptide Synthesis (SPPS) and solution-phase methods for introducing N-methylated threonine residues.
• Pharmaceutical Research: Used in the development of novel therapeutic peptides and peptidomimetics, particularly for metabolic diseases and oncology targets.
• Protease Inhibitor Development: Employed in the design and synthesis of inhibitors that mimic natural peptide substrates.
• Chemical Biology: Acts as a building block for creating labeled peptides, probes, and tools for studying protein-protein interactions.
• Agrochemical Synthesis: Utilized in the research and development of bioactive peptides for crop protection agents.
• Material Science: Serves as a precursor for synthesizing specialized polymers and dendrimers with tailored properties.

Basic Information

Item	Details
Product Name	n-Me-Thr(Tbu)-Oh
CAS No.	42417-72-1
Molecular Formula	C9H19NO3
Molecular Weight	189.25 g/mol
Synonyms	N-Methyl-O-tert-butyl-L-threonine; (2S,3R)-2-(Methylamino)-3-[(2-methylpropan-2-yl)oxy]butanoic acid; N-Methyl-L-threonine tert-butyl ether; Fmoc-N-Me-Thr(tBu)-OH (precursor form); Boc-N-Me-Thr(tBu)-OH (precursor form); N-Me-Thr(OtBu)-OH; N-Methyl-O-t-butylthreonine
EINECS	Contact for details

Quality Control

Our n-Me-Thr(Tbu)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.