Description

4,4,4-Trifluoro-3-Hydroxy-1-Phenyl-But-2-En-1-One is a high-value trifluoromethylated β-hydroxy enone building block, prized for its unique molecular architecture. This compound matters for its role as a versatile synthon in advanced organic synthesis, enabling the introduction of both fluorinated and hydroxylated motifs critical for modulating the properties of target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a building block for fluorinated organic frameworks and advanced polymers with tailored thermal and chemical resistance.
• Asymmetric Catalysis Substrate: Employed in academic and industrial research for developing new catalytic methodologies due to its prochiral centers.
• Ligand and Chelator Precursor: Utilized for synthesizing specialized ligands used in metal-catalyzed cross-coupling reactions.
• Fluorine Chemistry Studies: An important compound for investigating structure-activity relationships (SAR) in medicinal chemistry and the effects of fluorine substitution.

Basic Information

Product Name	4,4,4-Trifluoro-3-Hydroxy-1-Phenyl-But-2-En-1-One
CAS No.	41463-86-9
Molecular Formula	C10H7F3O2
Molecular Weight	216.16 g/mol
Synonyms	3-Hydroxy-4,4,4-trifluoro-1-phenyl-2-buten-1-one; 4,4,4-Trifluoro-3-hydroxybutyrophenone; 1-Phenyl-4,4,4-trifluoro-3-hydroxy-2-buten-1-one; 3-Hydroxy-4,4,4-trifluoro-1-phenylbut-2-en-1-one; TFHPE; Trifluoromethylated β-hydroxy enone; (Z)-4,4,4-Trifluoro-3-hydroxy-1-phenylbut-2-en-1-one
EINECS	Contact for details

Quality Control

Our 4,4,4-Trifluoro-3-Hydroxy-1-Phenyl-But-2-En-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided to guarantee reliable performance in your synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials. Due to its light-sensitive nature, handling should minimize prolonged exposure to ambient light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.