Description

Dimethyl (2-Oxo-4-Phenylbutyl)Phosphonate is a high-purity organophosphorus compound, specifically a phosphonate ester, serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a versatile reagent for the Horner-Wadsworth-Emmons (HWE) olefination reaction, enabling the efficient and stereoselective construction of complex α,β-unsaturated carbonyl systems. This makes it an indispensable material for research and development chemists and process engineers in the pharmaceutical and fine chemical industries, particularly for synthesizing active pharmaceutical ingredients (APIs) and complex intermediates.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing α,β-unsaturated ketone and aldehyde moieties, which are common scaffolds in drug molecules.
• Fine Chemical Production: Used in the synthesis of complex fragrance and flavor ingredients, as well as advanced materials precursors.
• Agrochemical Research: Employed in the development of novel active ingredients, particularly those requiring specific olefin geometries.
• Academic & R&D Laboratories: A staple reagent for methodological development in organic chemistry and for synthesizing novel compounds for biological screening.
• Process Chemistry: Valued for its reliability and selectivity in scaling up synthetic routes for commercial production under Good Manufacturing Practice (GMP) guidelines where applicable.

Basic Information

Product Name	Dimethyl (2-Oxo-4-Phenylbutyl)Phosphonate
CAS No.	41162-19-0
Molecular Formula	C₁₂H₁₇O₄P
Molecular Weight	256.23 g/mol
Synonyms	Dimethyl (4-Phenyl-2-oxobutyl)phosphonate; (2-Oxo-4-phenylbutyl)phosphonic Acid Dimethyl Ester; 4-Phenyl-2-oxobutylphosphonic Acid Dimethyl Ester; Phosphonic Acid, (2-Oxo-4-phenylbutyl)-, Dimethyl Ester; Dimethyl 2-Oxo-4-phenylbutylphosphonate; HWE Reagent for 4-Phenyl-3-buten-2-one
EINECS	Contact for details

Quality Control

Our Dimethyl (2-Oxo-4-Phenylbutyl)Phosphonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for pharmaceutical R&D and fine chemical synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management systems, and specifications can be aligned with customer requirements for specific applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.