Description

(1Ar,4E,7R,7Ar,10As,10Br)-7-Acetoxy-2,3,6,7,7A,8,10A,10B-Octahydro-1A,5-Dimethyl-8-Methyleneoxireno[9,10]Cyclodeca[1,2-B]Furan-9(1Ah)-One is a complex, high-purity sesquiterpene lactone derivative with a unique oxireno-fused cyclodecane structure, making it a valuable advanced pharmaceutical intermediate and a key scaffold for synthetic chemistry research. Its intricate molecular architecture provides a critical building block for the development of novel bioactive compounds, particularly in medicinal chemistry programs targeting specific therapeutic pathways. This compound is essential for R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex natural product analogs and proprietary active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those with terpenoid or lactone-based pharmacophores.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and the design of new chemical entities with potential biological activity.
• Natural Product Synthesis: Acts as a key intermediate in the total or semi-synthesis of complex natural products and their analogs for biological evaluation.
• Organic Synthesis Building Block: Provides a structurally unique template for exploring novel cycloaddition and ring-opening reactions in advanced synthetic methodology development.
• Biochemical Research: May be utilized as a probe or standard in studies investigating enzyme interactions or specific biological pathways influenced by sesquiterpene lactones.
• Reference Standard: Supplied as a high-purity compound for use as an analytical standard in quality control (QC) and research laboratories.

Basic Information

Item	Details
Product Name	(1Ar,4E,7R,7Ar,10As,10Br)-7-Acetoxy-2,3,6,7,7A,8,10A,10B-Octahydro-1A,5-Dimethyl-8-Methyleneoxireno[9,10]Cyclodeca[1,2-B]Furan-9(1Ah)-One
CAS No.	41059-80-7
Molecular Formula	C17H22O5
Molecular Weight	306.36 g/mol
Synonyms	7-Acetoxy-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methylideneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one; Parthenolide 7-acetate; 7-Acetylparthenolide; 7-O-Acetylparthenolide; (1aR,4E,7R,7aR,10aS,10bR)-7-(Acetyloxy)-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methylideneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
EINECS	Contact for details

Quality Control

Every batch of (1Ar,4E,7R,7Ar,10As,10Br)-7-Acetoxy-2,3,6,7,7A,8,10A,10B-Octahydro-1A,5-Dimethyl-8-Methyleneoxireno[9,10]Cyclodeca[1,2-B]Furan-9(1Ah)-One is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and fine chemical synthesis. A detailed Certificate of Analysis (COA) providing batch-specific results for purity, impurities, and identification is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light). Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Maximum Impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.