Description

5-(Trifluoromethyl)-1H-1,2,3-Triazole is a versatile heterocyclic building block characterized by a reactive triazole ring and a stable trifluoromethyl group. This combination is critical for modifying the physicochemical properties of target molecules, enhancing their metabolic stability, lipophilicity, and bioavailability. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the CF3 group improves efficacy and environmental profile.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, coatings, and liquid crystals with enhanced chemical resistance.
• Ligand in Catalysis: Employed in the design of N-heterocyclic carbene (NHC) precursors and other ligands for transition metal catalysis.
• Fluorine Chemistry Research: A valuable reagent for introducing the trifluoromethyl group into complex molecular architectures in medicinal and synthetic chemistry.

Basic Information

Product Name	5-(Trifluoromethyl)-1H-1,2,3-Triazole
CAS No.	40964-54-3
Molecular Formula	C3H2F3N3
Molecular Weight	137.06 g/mol
Synonyms	1H-1,2,3-Triazole, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)-1H-1,2,3-triazole; 5-Trifluoromethyl-1H-1,2,3-triazole; 3-Trifluoromethyl-1,2,3-triazole; 5-Trifluoromethyltriazole; 1,2,3-Triazole, 5-(trifluoromethyl)-; 40964-54-3
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)-1H-1,2,3-Triazole is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.