Description

4'-n-Butyl-2,2,2-Trifluoroacetophenone is a high-purity, versatile trifluoromethyl ketone intermediate of significant importance in advanced organic synthesis. Its unique structure, featuring a butyl chain and a reactive trifluoroacetyl group, makes it a critical building block for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers engaged in creating active pharmaceutical ingredients (APIs), liquid crystal materials, and specialized fine chemicals requiring fluorinated motifs.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially those incorporating trifluoromethyl groups to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies.
• Organic Synthesis Building Block: Employed in various name reactions and as a precursor for heterocyclic compounds, ligands, and catalysts.
• Material Science Research: Utilized in the development of specialty polymers and advanced organic materials with specific optical or electronic properties.

Basic Information

Product Name	4'-n-Butyl-2,2,2-Trifluoroacetophenone
CAS No.	40739-44-4
Molecular Formula	C₁₂H₁₃F₃O
Molecular Weight	230.23 g/mol
Synonyms	1-(4-Butylphenyl)-2,2,2-trifluoroethanone; 4'-Butyl-2,2,2-trifluoroacetophenone; 2,2,2-Trifluoro-1-(4-butylphenyl)ethanone; 4-n-Butyl-α,α,α-trifluoroacetophenone; p-Butyl-2,2,2-trifluoroacetophenone; 4-Butylphenyl trifluoromethyl ketone; TFAP-Bu; Contact for additional names.
EINECS	Contact for details

Quality Control

Our 4'-n-Butyl-2,2,2-Trifluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.