Description

3-(Trifluoromethyl)-3-Phenyldiaziridine is a specialized diaziridine derivative, a high-value building block in advanced organic synthesis. Its unique structure, featuring both a phenyl ring and a reactive trifluoromethyl-substituted diaziridine moiety, makes it a critical precursor for introducing photoaffinity labels and fluorinated functional groups into target molecules. This compound is essential for researchers and manufacturers in pharmaceutical discovery, agrochemical development, and materials science who require precise molecular tools for cross-linking studies and the synthesis of novel fluorinated compounds.

Application

• Photoaffinity Labeling Probes: A key reagent for synthesizing photoactivatable cross-linkers used in biochemistry and molecular biology to study protein-ligand interactions and identify binding sites.
• Pharmaceutical Intermediate: Serves as a versatile building block in the research and development of new active pharmaceutical ingredients (APIs), particularly those incorporating fluorine for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the creation of novel herbicides, pesticides, and fungicides where the diaziridine and trifluoromethyl groups contribute to unique biological activity and environmental persistence profiles.
• Materials Science Research: Employed in the development of advanced polymers and functional materials, where it can act as a cross-linking agent or a monomer to introduce specific photo-reactive or fluorinated properties.
• Bioconjugation Chemistry: Facilitates the site-specific labeling of biomolecules (proteins, nucleic acids) for diagnostic assays, imaging, and targeted drug delivery systems.
• Organic Synthesis Reagent: Provides a source of the diaziridine functional group for cycloaddition reactions and the construction of nitrogen-containing heterocycles in medicinal chemistry.

Basic Information

Product Name	3-(Trifluoromethyl)-3-Phenyldiaziridine
CAS No.	40618-96-0
Molecular Formula	C9H7F3N2
Molecular Weight	200.16 g/mol
Synonyms	3-Phenyl-3-(trifluoromethyl)diaziridine; 3-Trifluoromethyl-3-phenyldiaziridine; Diaziridine, 3-phenyl-3-(trifluoromethyl)-; 3-Phenyl-3-(trifluoromethyl)diazacyclopropane; α-Phenyl-α-(trifluoromethyl)diaziridine; 1-Phenyl-1-(trifluoromethyl)diaziridine; 3-(Trifluoromethyl)-3-phenyl-diaziridine; 40618-96-0
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)-3-Phenyldiaziridine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure it meets the exacting standards required for research and synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.