Description

L-Threo-Methylphenidate Hydrochloride is a specific stereoisomer of the central nervous system stimulant methylphenidate. This high-purity enantiomer is critical for advanced pharmaceutical research and development, particularly in the study of receptor-specific activity and the formulation of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers focused on neurology and psychiatry.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for quality control and analytical method development in drug manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the research and synthesis of enantiomerically pure pharmaceutical compounds.
• Neuroscience Research: A key tool for in-vitro and in-vivo studies investigating the mechanisms of dopamine and norepinephrine reuptake inhibition.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research related to methylphenidate therapies.
• Analytical Chemistry: Used as a high-purity calibrant in chromatographic (HPLC, GC) and spectroscopic analyses.

Basic Information

Product Name	L-Threo-Methylphenidate Hydrochloride
CAS No.	40572-71-2
Molecular Formula	C14H19NO2 • HCl
Molecular Weight	269.77 g/mol (Free base: 233.31 g/mol)
Synonyms	(-)-threo-Methylphenidate Hydrochloride; L-Methylphenidate HCl; (2R,2'R)-Methylphenidate Hydrochloride; d-threo-Methylphenidate Hydrochloride; Ritatin; Focalin Impurity; Methyl α-phenyl-2-piperidineacetate hydrochloride; ADHD Research Compound
EINECS	Contact for details

Quality Control

Our L-Threo-Methylphenidate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets stringent specifications for research and development use. A detailed Certificate of Analysis (COA) providing results for identity, purity, and related substances is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.