Description

Dexmethylphenidate CAS NO 40431-64-9 is the pharmacologically active d-threo enantiomer of methylphenidate, a central nervous system stimulant. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and consistency of finished pharmaceutical products. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of treatments for Attention Deficit Hyperactivity Disorder (ADHD) and narcolepsy.

Application

• Primary Active Pharmaceutical Ingredient (API) in the formulation of extended-release and immediate-release prescription medications for ADHD.
• Key component in generic and branded pharmaceutical products targeting central nervous system disorders.
• Reference standard for analytical method development and validation in quality control laboratories.
• Critical material for clinical research and preclinical studies investigating stimulant pharmacology.
• Starting material or intermediate for advanced pharmaceutical research and development (R&D) of novel therapeutics.
• Used in the manufacture of controlled-release drug delivery systems to optimize therapeutic profiles.

Basic Information

Product Name	Dexmethylphenidate
CAS No.	40431-64-9
Molecular Formula	C₁₄H₁₉NO₂
Molecular Weight	233.31 g/mol
Synonyms	d-Methylphenidate; (+)-Methylphenidate; (2R,2'R)-(+)-Threo-Methylphenidate; Dexmethylphenidate Hydrochloride (salt form); Focalin (trade name); d-threo-Methylphenidate; (R,R)-Methylphenidate; α-Phenyl-2-piperidineacetic acid methyl ester
EINECS	Contact for details

Quality Control

Our Dexmethylphenidate is manufactured under strict quality systems to meet the rigorous standards of the pharmaceutical industry. Quality is assured through comprehensive analytical testing, including chiral purity verification, to ensure compliance with relevant pharmacopeial monographs (e.g., USP). A detailed Certificate of Analysis (COA) is provided with each batch, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Microbial Enumeration	Meets Ph. Eur./USP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.