Description

L-Erythro-Methylphenidate Hydrochloride is a high-purity, stereochemically defined active pharmaceutical ingredient (API) and a key intermediate in advanced pharmaceutical synthesis. This compound is critical for research and development in neuropharmacology, particularly for studying stereospecific drug-receptor interactions and developing novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories, analytical reference standard producers, and manufacturers of specialty fine chemicals targeting the central nervous system.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the analytical method development and validation of related drug substances and products.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical chiral building block in the synthesis of advanced pharmaceutical compounds targeting neurological pathways.
• Pharmacological Research: Employed in preclinical studies to investigate the structure-activity relationship (SAR) and enantiomeric specificity of stimulant-class compounds.
• Analytical Chemistry: Utilized as a high-purity standard in chromatographic (HPLC, GC) and spectroscopic analyses for qualitative and quantitative purposes.
• Process Development & Optimization: Acts as a model compound for developing and scaling up stereoselective synthesis and purification processes.
• Regulatory & Quality Control: Essential for compliance testing, impurity profiling, and stability studies in a GMP environment.

Basic Information

Product Name	L-Erythro-Methylphenidate Hydrochloride
CAS No.	40431-63-8
Molecular Formula	C14H19NO2·HCl
Molecular Weight	269.77 g/mol (Free base: 233.31 g/mol)
Synonyms	(-)-Erythro-Methylphenidate Hydrochloride; (2R,2'R)-Methylphenidate Hydrochloride; L-threo-Methylphenidate Hydrochloride (obsolete nomenclature); d-threo-Methylphenidate Hydrochloride; Ritalinic Acid Methyl Ester Hydrochloride (L-erythro-); (R,R)-Methylphenidate HCl; α-Phenyl-2-piperidineacetic acid methyl ester hydrochloride (erythro-); MPI HCl
EINECS	Contact for details

Quality Control

Our L-Erythro-Methylphenidate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination, to ensure it meets stringent specifications for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral excess, residual solvents, and related substances is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Chiral Purity (Chiral HPLC)	≥99.0% (L-erythro isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Related Substances (HPLC)	Any individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.