Description

2-Bromo-5-Fluorobenzotrifluoride is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both bromine and fluorine substituents on a trifluoromethylated benzene ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and as a precursor to active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine and bromine atoms enhance biological activity and stability.
• Material Science: Serves as a monomer or precursor in the development of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for metal-catalyzed reactions like Suzuki, Negishi, and Stille couplings to form new carbon-carbon bonds.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries.
• Ligand and Catalyst Development: Used to synthesize complex ligands for catalysis and molecular recognition applications.

Basic Information

Product Name	2-Bromo-5-Fluorobenzotrifluoride
CAS No.	40161-55-5
Molecular Formula	C7H3BrF4
Molecular Weight	243.00 g/mol
Synonyms	1-Bromo-4-fluoro-2-(trifluoromethyl)benzene; 2-Bromo-α,α,α-trifluoro-5-fluorotoluene; 5-Fluoro-2-bromobenzotrifluoride; 4-Fluoro-2-(trifluoromethyl)bromobenzene; 2-Bromo-5-fluorobenzylidene trifluoride; 2-Bromo-5-fluorotrifluorotoluene; Benzene, 1-bromo-4-fluoro-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Fluorobenzotrifluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.7 g/mL
Boiling Point	~185-190 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.