Description

1-Bromo-3-Chlorocyclobutane is a versatile halogenated cyclobutane derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and chlorine substituents on a strained four-membered ring, makes it a valuable precursor for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, where it is used to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the cyclobutane ring can impart specific biological activity.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis and cross-coupling reactions.
• Polymer & Materials Science: Employed in the synthesis of monomers and specialty polymers, contributing to materials with unique thermal or mechanical properties.
• Organic Synthesis Building Block: Utilized in ring-opening, substitution, and cross-coupling reactions (e.g., Suzuki, Negishi) to introduce functionalized cyclobutyl groups into target molecules.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D exploring new reaction methodologies and the properties of strained ring systems.

Basic Information

Product Name	1-Bromo-3-Chlorocyclobutane
CAS No.	4935-03-9
Molecular Formula	C4H6BrCl
Molecular Weight	169.45 g/mol
Synonyms	3-Chloro-1-bromocyclobutane; Cyclobutane, 1-bromo-3-chloro-; 1-Bromo-3-chloro-cyclobutane; Bromochlorocyclobutane; NSC 523258; 1-Chloro-3-bromocyclobutane (possible positional isomer); trans/cis-1-Bromo-3-chlorocyclobutane (mixture)
EINECS	225-575-9

Quality Control

Our 1-Bromo-3-Chlorocyclobutane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, NMR, and purity assays, to ensure it meets the high standards required for research and industrial synthesis. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support compliance with global regulatory frameworks, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and active metals. Recommended storage temperature is between 2°C and 8°C for extended stability, although the product is stable at controlled room temperature for shorter periods. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.6 g/mL
Boiling Point	~75-80°C @ 20 mmHg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.