Description

1-Bromo-4-[(difluoromethyl)sulfanyl]benzene is a specialized organosulfur and organofluorine compound that serves as a versatile building block in advanced chemical synthesis. Its unique structure, featuring both bromine and a difluoromethylthio group, makes it a valuable reagent for introducing sulfur-fluorine motifs into target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring sulfur-fluorine bioisosteres to modulate potency, metabolic stability, and membrane permeability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the difluoromethylthio group can enhance biological activity and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of advanced polymers, liquid crystals, and electronic materials with specific optical or electronic properties.
• Cross-Coupling Reactions: The aryl bromide moiety enables participation in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) for complex molecule assembly.
• Radical Chemistry: Potential substrate in radical-mediated reactions for C-S or C-C bond formation, facilitated by the reactive S-CF2H group.
• Chemical Biology Probes: Useful for labeling or modifying biomolecules in drug discovery and proteomics research due to its selective reactivity.

Basic Information

Product Name	1-Bromo-4-[(difluoromethyl)sulfanyl]benzene
CAS No.	4837-14-3
Molecular Formula	C7H5BrF2S
Molecular Weight	239.08 g/mol
Synonyms	4-Bromophenyl difluoromethyl sulfide; p-Bromophenyl difluoromethyl sulfide; 1-Bromo-4-(difluoromethylthio)benzene; (4-Bromophenyl)(difluoromethyl) sulfide; Benzene, 1-bromo-4-[(difluoromethyl)thio]-; Difluoromethyl 4-bromophenyl sulfide
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-[(difluoromethyl)sulfanyl]benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in cGMP environments and research requiring the highest material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its sensitivity to light and potential for oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.