Description

Methyl 2-Chloroacetoacetate is a versatile and reactive organic ester, serving as a key building block in fine chemical synthesis. Its value lies in the presence of both a reactive chloro and a carbonyl group, enabling its use in a variety of condensation and substitution reactions. This compound is primarily needed by manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for the production of active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of various heterocyclic compounds, including pyrazoles and pyrimidines, which are core structures in many active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the manufacturing of herbicides, fungicides, and insecticides, where it acts as a key intermediate for introducing specific functional groups.
• Dye and Pigment Production: Serves as a building block for synthesizing complex organic dyes and pigments, particularly azo dyes.
• Chemical Research & Development: Employed in organic synthesis laboratories for developing new methodologies and creating novel molecular structures.
• Flavor and Fragrance Industry: Utilized as an intermediate in the synthesis of certain aroma chemicals and flavoring agents.

Basic Information

Product Name	Methyl 2-Chloroacetoacetate
CAS No.	4755-81-1
Molecular Formula	C5H7ClO3
Molecular Weight	150.56 g/mol
Synonyms	Methyl chloroacetoacetate; 2-Chloroacetoacetic acid methyl ester; Methyl 2-chloro-3-oxobutanoate; Acetoacetic acid, 2-chloro-, methyl ester; 3-Oxobutanoic acid, 2-chloro-, methyl ester; Chloroacetoacetic acid methyl ester
EINECS	225-285-7

Quality Control

Our Methyl 2-Chloroacetoacetate is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for every shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, and we support our customers' regulatory needs for pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Specific Gravity (20°C)	1.25 - 1.35
Refractive Index (20°C)	1.435 - 1.445

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.