Description

Adenosine-2',3'-o-Phenylboronate is a chemically modified nucleoside derivative where a phenylboronate group is esterified to the 2' and 3' hydroxyls of the ribose sugar. This compound is a crucial intermediate and protecting group reagent in the synthesis of modified oligonucleotides and nucleoside analogs. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced nucleic acid chemistry, drug discovery, and the development of diagnostic probes. Its unique structure facilitates selective reactions and is essential for creating sophisticated molecular tools.

Application

• Oligonucleotide Synthesis: Serves as a key intermediate and protecting group for the ribose moiety during solid-phase and solution-phase synthesis of RNA and modified DNA strands.
• Pharmaceutical Research: Used in the development of nucleoside-based prodrugs and antiviral/anticancer agents, where the boronate ester acts as a transient protecting group or a functional handle.
• Bioconjugation Chemistry: Acts as a reactive handle for attaching adenosine derivatives to other molecules, surfaces, or nanoparticles for diagnostic and sensor applications.
• Chemical Biology Probes: Employed in the creation of activity-based probes and affinity labels to study adenosine-binding proteins and enzymes.
• Material Science: Potential use in the development of boronate-based polymeric materials and sensors that respond to diols or changes in pH.

Basic Information

Item	Detail
Product Name	Adenosine-2',3'-o-Phenylboronate
CAS No.	4710-68-3
Molecular Formula	C17H18BN5O5
Molecular Weight	383.17 g/mol
Synonyms	2',3'-O-(Phenylboronate)adenosine; Adenosine 2',3'-Phenylboronate; 9-β-D-Ribofuranosyladenine 2',3'-(phenylboronate); 2',3'-O-(Phenylboronic Ester) Adenosine; Adenosine Phenylboronate Ester; N6-Adenosine Phenylboronate (ambiguous, but sometimes used); A2'3'PhB (abbreviation)
EINECS	Contact for details

Quality Control

Our Adenosine-2',3'-o-Phenylboronate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.