Description

Grayanotoxin Iii is a naturally occurring diterpenoid compound, also known as andromedotoxin, which is a key bioactive constituent found in plants of the Ericaceae family. This compound is of significant interest in biochemical and pharmacological research due to its potent neurotoxic activity as a sodium channel activator. It serves as a critical reference standard and research material for scientists in toxicology, natural product chemistry, and neuroscience, enabling the study of ion channel function and the development of analytical methods for toxin detection.

Application

• Pharmacological Research: Used as a reference standard in studies investigating sodium channel gating mechanisms and neurotoxicity.
• Toxicology & Safety Assessment: Essential for developing and validating analytical methods (e.g., HPLC, LC-MS) to detect and quantify grayanotoxins in food, environmental, and clinical samples.
• Natural Product Chemistry: Serves as a purified marker compound for the isolation, identification, and quality control of plant extracts from Rhododendron, Kalmia, and other related genera.
• Neuroscience Studies: Utilized as a tool compound to probe the function of voltage-gated sodium channels in neuronal cell lines and tissue preparations.
• Reference Standard Manufacturing: Supplied to laboratories and diagnostic kit manufacturers for use as a high-purity calibrant in certified reference materials (CRMs).
• Academic & Institutional Research: Provides a key reagent for universities and research institutes studying plant-derived toxins and their biological effects.

Basic Information

Product Name	Grayanotoxin Iii
CAS No.	4678-45-9
Molecular Formula	C22H36O7
Molecular Weight	412.52 g/mol
Synonyms	Andromedotoxin; Acetylandromedol; Grayanotoxin-3; Rhodotoxin; Grayanotaxin III; 3,5,6,14,16-Pentahydroxygrayanotoxane-10(20)-ene 6-acetate; (1R,2S,5S,6R,9S,11R,12S,14R)-5,6,14,16-Tetrahydroxy-3,11-epoxygrayanotox-10(20)-en-2-yl acetate
EINECS	Contact for details

Quality Control

Our Grayanotoxin Iii is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation, to ensure identity, potency, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0 %
Residue on Ignition	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.