Description

5-Nitrothiophene-2-Carboxaldehyde is a high-purity, versatile heterocyclic building block essential for advanced organic synthesis. Its unique structure, featuring both a nitro group and an aldehyde functionality on a thiophene ring, makes it a critical precursor for constructing complex molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, leveraging its reactive sites for structural diversification.
• Material Science Research: Serves as a building block for creating functional polymers, organic semiconductors, and non-linear optical (NLO) materials due to the electron-withdrawing nitro group.
• Chemical Research & Development: Employed in academic and industrial R&D labs for heterocyclic chemistry, cross-coupling reactions, and as a scaffold for library synthesis in high-throughput screening.
• Dye and Pigment Precursor: Acts as an intermediate in the synthesis of specialized dyes and pigments where the thiophene core contributes to color and stability properties.
• Ligand and Catalyst Development: Useful for synthesizing novel ligands for metal catalysis or as a component in organocatalyst design.

Basic Information

Product Name	5-Nitrothiophene-2-Carboxaldehyde
CAS No.	4521-33-9
Molecular Formula	C5H3NO3S
Molecular Weight	157.15 g/mol
Synonyms	2-Formyl-5-nitrothiophene; 5-Nitro-2-thiophenecarboxaldehyde; 5-Nitrothiophene-2-carbaldehyde; 2-Thiophenecarboxaldehyde, 5-nitro-; 5-Nitro-2-thiophenecarbaldehyde; 5-Nitrothiophene-2-aldehyde; 5-Nitro-2-formylthiophene
EINECS	Contact for details

Quality Control

Every batch of 5-Nitrothiophene-2-Carboxaldehyde is manufactured and tested under strict quality management protocols to ensure consistency and reliability for your critical applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity, the container should be kept under an inert atmosphere to minimize oxidation and moisture uptake. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	108 - 112 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.