Description

3-Chloro-3-Phenyldiazirine is a specialized diazirine-based photoaffinity labeling reagent, a critical tool for studying biomolecular interactions. Its core value lies in its ability to form highly reactive carbenes upon photolysis, enabling the covalent cross-linking of proteins, nucleic acids, and other biological molecules for structural and functional analysis. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and chemical biology who require precise tools for target identification and binding site mapping.

Application

• Photoaffinity Labeling (PAL): A key reagent for covalent cross-linking in the study of protein-ligand, protein-protein, and protein-nucleic acid interactions.
• Proteomics Research: Used to identify and characterize unknown binding sites and transient interactions within complex biological systems.
• Drug Discovery: Employed in target validation and mechanism-of-action studies to create irreversible probes from lead compounds.
• Chemical Biology Tool Development: Serves as a versatile building block for synthesizing advanced probes and tags for bioorthogonal chemistry.
• Materials Science: Potential use in surface functionalization and polymer cross-linking via carbene insertion chemistry.

Basic Information

Product Name	3-Chloro-3-Phenyldiazirine
CAS No.	4460-46-2
Molecular Formula	C7H5ClN2
Molecular Weight	152.58 g/mol
Synonyms	3-Chloro-3-phenyldiaziridine; Phenyldiazirine, 3-chloro-; 3-Phenyldiazirine, 3-chloro-; Diaziridine, 3-chloro-3-phenyl-; 3-Chloro-3-phenyl-diaziridine; 3-Chloro-3-phenyl-diazirine; (Chlorophenyl)diazirine
EINECS	Contact for details

Quality Control

Our 3-Chloro-3-Phenyldiazirine is produced and handled under strict quality protocols to ensure high purity and batch-to-batch consistency, critical for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability. We adhere to cGMP principles where applicable to support our clients in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the product label or COA. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Yellow to orange liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.