Description

3-Hydroxy-2,2-Diphenylpropionic Acid is a versatile organic compound featuring a chiral center and a carboxylic acid functional group, making it a valuable intermediate in fine chemical synthesis. Its molecular structure is critical for the production of high-value pharmaceuticals and advanced materials where precise stereochemistry is required. This compound is essential for research and manufacturing chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients or chiral building blocks.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and metabolic disorders.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, where its diphenyl moiety contributes to biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Polymer Modification: Employed to introduce specific functional groups into polymer chains, enhancing material properties for specialty coatings and resins.
• Academic and R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.
• Fine Chemical Production: Integral to the multi-step synthesis of complex fragrance molecules and other high-value specialty chemicals.

Basic Information

Item	Details
Product Name	3-Hydroxy-2,2-Diphenylpropionic Acid
CAS No.	4448-72-0
Molecular Formula	C15H14O3
Molecular Weight	242.27 g/mol
Synonyms	2,2-Diphenyl-3-hydroxypropionic acid; α-Hydroxydiphenylacetic acid β-hydroxyethyl ester (related); Benzhydryl glycolic acid; 3-Hydroxy-2,2-diphenylpropanoic acid; NSC 163082; Diphenylhydroxyacetic acid lactone precursor; (RS)-3-Hydroxy-2,2-diphenylpropionic acid; α,α-Diphenyl-β-hydroxypropionic acid
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-2,2-Diphenylpropionic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets stringent specifications for use in sensitive applications. Certificates of Analysis (COA) detailing all test results are provided and we can support compliance with cGMP and ISO standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.