Description

2-Phenyl-1,3,2-Dioxaborolane is a versatile cyclic boronic ester, a key intermediate in modern synthetic chemistry. Its primary value lies in its role as a protected boronic acid, offering enhanced stability and solubility for various cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for complex molecule synthesis.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A fundamental reagent for forming carbon-carbon bonds in the synthesis of biaryl compounds, a common motif in active pharmaceutical ingredients (APIs) and organic electronic materials.
• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of drug candidates, particularly those containing aryl and heteroaryl segments.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that require specific aryl-boron functionalities.
• Material Science & OLED Development: Employed in the creation of organic light-emitting diode (OLED) materials and other functional polymers where precise molecular architecture is crucial.
• Organic Synthesis & Methodology: Acts as a stable boronate source in palladium-catalyzed and other transition metal-catalyzed transformations for academic and industrial R&D.
• Protecting Group Strategy: The dioxaborolane moiety effectively protects boronic acids from decomposition, allowing for sequential synthetic steps.

Basic Information

Item	Detail
Product Name	2-Phenyl-1,3,2-Dioxaborolane
CAS No.	4406-72-8
Molecular Formula	C8H9BO2
Molecular Weight	147.97 g/mol
Synonyms	Phenylboronic Acid Ethylene Ester; 2-Phenyl-1,3,2-dioxaborolane; 2-Phenyl-1,3,2-dioxaborinane; Phenylboronic Acid Cyclic Ethylene Ester; Benzeneboronic Acid, Cyclic Ethylene Ester; Ethylene Phenylboronate; CAS 4406-72-8
EINECS	Contact for details

Quality Control

Every batch of our 2-Phenyl-1,3,2-Dioxaborolane is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC or 1H NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.