Description

3-Hydroxy-2-(4-Chlorophenyl)Acrylic Acid Ethyl Ester is a versatile and high-value organic intermediate characterized by its α,β-unsaturated ester structure with both phenolic and chlorophenyl functional groups. This compound is essential for the synthesis of complex molecules, offering a reactive scaffold for constructing pharmacologically active cores and advanced materials. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs), COX-2 inhibitors, and other therapeutic agents.
• Agrochemical Synthesis: Used in the production of advanced fungicides and herbicides, leveraging the chlorophenyl moiety for bioactivity.
• Organic Light-Emitting Diodes (OLEDs): Serves as a precursor for electron-transport materials or host materials in emissive layers due to its conjugated system.
• Ligand and Catalyst Development: Utilized in coordination chemistry to create novel ligands for metal-catalyzed cross-coupling reactions.
• Polymer Modification: Acts as a functional monomer or cross-linking agent to introduce specific properties like UV-absorption or chemical resistance into polymers.
• Academic and R&D: Employed in medicinal chemistry research for structure-activity relationship (SAR) studies and novel compound library synthesis.

Basic Information

Product Name	3-Hydroxy-2-(4-Chlorophenyl)Acrylic Acid Ethyl Ester
CAS No.	4383-55-5
Molecular Formula	C11H11ClO3
Molecular Weight	226.66 g/mol
Synonyms	Ethyl 3-Hydroxy-2-(4-chlorophenyl)acrylate; 2-(4-Chlorophenyl)-3-hydroxyacrylic Acid Ethyl Ester; Ethyl (2E)-3-Hydroxy-2-(4-chlorophenyl)prop-2-enoate; 4-Chlorobenzalpyruvic Acid Ethyl Ester; (E)-Ethyl 3-hydroxy-2-(4-chlorophenyl)acrylate; 3-Hydroxy-2-(p-chlorophenyl)acrylic Acid Ethyl Ester; NSC 403697
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-2-(4-Chlorophenyl)Acrylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles. Our quality commitment aligns with cGMP standards where applicable, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed after use to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.