Description

5-Formyl-2-Thiopheneboronic Acid is a high-value organoboron building block featuring both a formyl and a boronic acid functional group on a thiophene scaffold. This unique bifunctional structure makes it a critical intermediate for the synthesis of complex molecules via cross-coupling reactions and subsequent derivatization. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel heterocyclic compounds and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of new herbicides and fungicides, leveraging the thiophene moiety for enhanced biological activity.
• Material Science Research: Serves as a monomer or building block for creating conjugated polymers and organic electronic materials like OLEDs and organic photovoltaics.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and sensors due to its reactive aldehyde group for bioconjugation.
• Ligand Development: Useful for preparing novel bidentate ligands for catalysis in asymmetric synthesis and transition metal complexes.

Basic Information

Item	Details
Product Name	5-Formyl-2-Thiopheneboronic Acid
CAS No.	4347-33-5
Molecular Formula	C5H5BO3S
Molecular Weight	155.97 g/mol
Synonyms	2-Formyl-5-thiopheneboronic acid; (5-Formylthiophen-2-yl)boronic acid; 5-Formylthiophene-2-boronic acid; 2-Borono-5-formylthiophene; Thiophene-2-boronic acid, 5-formyl-; 5-Carboxaldehydethiophene-2-boronic Acid; 5-Formyl-2-thienylboronic acid
EINECS	Contact for details

Quality Control

Our 5-Formyl-2-Thiopheneboronic Acid is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.