Description

(1Z)-2,2,2-Trifluoro-N'-Hydroxyethanimidamide (Saltdata: Free) is a high-purity trifluoromethyl-substituted amidoxime derivative, a versatile building block in advanced organic synthesis. Its core value lies in enabling the efficient introduction of the trifluoromethyl group and the amidoxime functional handle, which are critical for modulating the physicochemical properties of target molecules. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty materials sectors seeking to develop novel compounds with enhanced metabolic stability, lipophilicity, and biological activity.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental stability.
• Ligand & Chelating Agent Precursor: Serves as a precursor for nitrogen-oxygen donor ligands used in catalysis and metal complexation.
• Material Science Research: Building block for novel polymers, coatings, and functional materials requiring specific fluorine-based properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological mechanisms.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	(1Z)-2,2,2-Trifluoro-N'-Hydroxyethanimidamide (Saltdata: Free)
CAS No.	4314-35-6
Molecular Formula	C2H3F3N2O
Molecular Weight	128.05 g/mol
Synonyms	2,2,2-Trifluoroacetamidoxime; Trifluoroacetamidoxime; (Z)-2,2,2-Trifluoroacetamidoxime; (1Z)-2,2,2-Trifluoroacetimidic Acid Amide Oxime; N-Hydroxy-2,2,2-trifluoroacetamidine; 2,2,2-Trifluoro-N-hydroxyethanimidamide; TFA Amidoxime; CF3C(=NOH)NH2
EINECS	Contact for details

Quality Control

Our production of (1Z)-2,2,2-Trifluoro-N'-Hydroxyethanimidamide adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements, supporting applications in GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.