Description

Methylbromodiazirine is a specialized, high-energy diazirine compound widely utilized as a versatile photoaffinity labeling reagent. Its core value lies in its ability to generate highly reactive carbene intermediates upon photolysis, enabling the covalent cross-linking and study of biomolecular interactions. This product is essential for researchers and developers in pharmaceutical discovery, chemical biology, and proteomics who require precise tools for mapping protein-ligand binding sites and investigating complex biological mechanisms.

Application

• Photoaffinity Labeling (PAL): A critical reagent for covalently tagging biological targets (proteins, nucleic acids) upon light activation to study binding sites and interactions.
• Chemical Biology & Proteomics: Used to create functionalized probes for target identification, activity-based protein profiling (ABPP), and understanding metabolic pathways.
• Drug Discovery & Medicinal Chemistry: Employed in the development of covalent inhibitors and for elucidating the molecular mechanisms of drug action.
• Bioconjugation & Material Science: Serves as a photochemical cross-linker for surface functionalization and the creation of novel biomaterials.
• Organic Synthesis Intermediate: Acts as a precursor for synthesizing more complex molecules containing the diazirine or bromomethyl functional groups.

Basic Information

Product Name	Methylbromodiazirine
CAS No.	4222-23-5
Molecular Formula	C2H3BrN2
Molecular Weight	134.96 g/mol
Synonyms	3-Bromo-3-methyldiazirine; Bromomethyldiazirine; Diaziridine, 3-bromo-3-methyl-; 3-Methyl-3-bromodiazirine; Methyl bromodiazirine; Photoaffinity labeling reagent MBrD; MBrD; (Bromomethyl)diazirine
EINECS	Contact for details

Quality Control

Our Methylbromodiazirine is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic identification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at recommended temperatures between -20°C to -10°C to maintain stability. Due to its light-sensitive nature and potential thermal sensitivity, prolonged exposure to ambient light or elevated temperatures should be avoided.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.