Description

2-Chloro-1-(4-Iodophenyl)Ethanone is a versatile halogenated aromatic ketone building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both chloro and iodo substituents, makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists working on novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, leveraging its reactive halogen sites for further functionalization.
• Material Science Research: Serves as a building block for creating specialized polymers and liquid crystals with unique electronic or optical properties.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form biaryl structures.
• Heterocyclic Chemistry: Utilized in the construction of various heterocyclic scaffolds, such as benzofurans and indoles, which are common motifs in bioactive molecules.
• Chemical Biology Probes: Acts as a starting material for synthesizing molecular probes used to study biological pathways and enzyme functions.

Basic Information

Product Name	2-Chloro-1-(4-Iodophenyl)Ethanone
CAS No.	4209-04-5
Molecular Formula	C8H6ClIO
Molecular Weight	280.49 g/mol
Synonyms	4'-Iodo-2-chloroacetophenone; 2-Chloro-1-(4-iodophenyl)ethan-1-one; 4-Iodophenacyl Chloride; p-Iodophenacyl Chloride; 2-Chloro-4'-iodoacetophenone; α-Chloro-4-iodoacetophenone; 1-(4-Iodophenyl)-2-chloroethanone; NSC 403697
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-1-(4-Iodophenyl)Ethanone is produced and tested under a strict quality management system. We ensure high purity and consistency suitable for demanding research and development applications. Our products undergo rigorous quality testing, including HPLC, NMR, and GC-MS analysis, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	92 - 96 °C
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.