Description

(4-Methylphenylethynyl)Trimethylsilane is a specialized organosilicon compound featuring a trimethylsilyl-protected alkyne group attached to a p-tolyl ring. This molecular architecture makes it a valuable protected acetylene synthon and a versatile building block in advanced organic synthesis. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science sectors for constructing complex molecular frameworks through cross-coupling and deprotection strategies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing acetylene functionalities in a protected form.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and plant growth regulators that require tailored aromatic-alkyne structures.
• Material Science & OLED Development: Acts as a precursor for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs) and electronic materials.
• Cross-Coupling Reactions: An essential reagent in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Ligand & Catalyst Preparation: Employed in the synthesis of sophisticated ligands and organometallic catalysts for asymmetric synthesis.
• Academic & Industrial R&D: A fundamental tool for synthetic organic chemists exploring new reaction methodologies and molecular architectures.

Basic Information

Product Name	(4-Methylphenylethynyl)Trimethylsilane
CAS No.	4186-14-5
Molecular Formula	C₁₂H₁₆Si
Molecular Weight	188.34 g/mol
Synonyms	1-Trimethylsilyl-2-(p-tolyl)acetylene; p-Tolylethynyltrimethylsilane; 4-Methylphenylethynyltrimethylsilane; Trimethyl((4-methylphenyl)ethynyl)silane; 4-Methylphenyl ethynyl trimethyl silane; TMS-protected p-tolylacetylene; (p-Tolylethynyl)trimethylsilane
EINECS	Contact for details

Quality Control

Our (4-Methylphenylethynyl)Trimethylsilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.