Description

2-Chloro-5-(Methylsulfonyl)Benzotrifluoride is a high-value, multi-functional aromatic building block characterized by its trifluoromethyl and methylsulfonyl substituents. This compound is essential for synthesizing advanced molecules where electron-withdrawing groups and halogen handles are required for further functionalization. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its unique halogenated sulfone structure.
• Material Science: Serves as a precursor for specialty polymers and liquid crystals, where the trifluoromethyl group imparts desirable stability and electronic properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution due to the reactive chlorine atom.
• Dye and Pigment Intermediate: Utilized in the synthesis of complex, high-performance colorants for specialized applications.

Basic Information

Product Name	2-Chloro-5-(Methylsulfonyl)Benzotrifluoride
CAS No.	4163-81-9
Molecular Formula	C8H6ClF3O2S
Molecular Weight	258.64 g/mol
Synonyms	2-Chloro-α,α,α-trifluoro-5-(methylsulfonyl)toluene; 1-Chloro-4-(methylsulfonyl)-2-(trifluoromethyl)benzene; 2-Chloro-5-(methanesulfonyl)benzotrifluoride; 5-(Methylsulfonyl)-2-chlorobenzotrifluoride; 2-Chloro-α,α,α-trifluoro-5-methylsulfonyltoluene; Benzene, 1-chloro-4-(methylsulfonyl)-2-(trifluoromethyl)-; 2-Chlor-5-(methylsulfonyl)benzotrifluorid
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-(Methylsulfonyl)Benzotrifluoride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.