Description

2-Hydroxy-3-Methylbutyric Acid is a branched-chain hydroxy acid that serves as a versatile chiral building block in organic synthesis. Its value lies in its ability to introduce both hydroxyl and carboxylic acid functionalities, enabling the synthesis of complex molecules with specific stereochemistry. This compound is particularly relevant for manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediates: A key chiral synthon for the production of active pharmaceutical ingredients (APIs), especially in the synthesis of β-lactam antibiotics and other therapeutics.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and plant growth regulators where specific stereoisomers are required for efficacy.
• Flavor and Fragrance Industry: Acts as a precursor for esters and lactones that contribute to fruity and creamy flavor notes in food products and perfumes.
• Biochemical Research: Serves as a standard or reagent in metabolic studies, particularly related to branched-chain amino acid (e.g., leucine) catabolism.
• Polymer Modification: Utilized to introduce functional groups into polymer chains, enhancing properties like biodegradability or adhesion.
• Cosmetic Ingredients: A potential intermediate for synthesizing skin-conditioning agents and mild exfoliants in cosmetic formulations.

Basic Information

Product Name	2-Hydroxy-3-Methylbutyric Acid
CAS No.	4026-18-0
Molecular Formula	C5H10O3
Molecular Weight	118.13 g/mol
Synonyms	3-Methyl-2-hydroxybutyric acid; α-Hydroxyisovaleric acid; 2-Hydroxy-3-methylbutanoic acid; (RS)-2-Hydroxy-3-methylbutyric acid; DL-2-Hydroxy-3-methylbutyric acid; (±)-2-Hydroxy-3-methylbutyric acid; Hydroxymethylbutyric acid; HMB precursor
EINECS	223-695-1

Quality Control

We maintain strict quality assurance protocols for 2-Hydroxy-3-Methylbutyric Acid, ensuring batch-to-batch consistency and high purity. Our standard grade typically meets a specification of ≥98.0% purity (by HPLC), with rigorous testing for identity, assay, and specific impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We can also supply material compliant with ICH guidelines for pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture, which may affect quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0 %
Melting Point	78°C - 82°C
Loss on Drying	≤ 1.0 %
Specific Rotation	-0.10° to +0.10° (c=1 in H2O)
Heavy Metals (as Pb)	≤ 10 ppm
Residue on Ignition	≤ 0.1 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.