Description

2,3,4,5,6-Pentamethylbenzyl Chloride is a highly substituted benzyl chloride derivative, serving as a versatile and valuable synthetic intermediate in advanced organic chemistry. Its unique sterically hindered structure makes it a critical building block for introducing the pentamethylbenzyl group, which is prized for its electronic and steric properties in material science and pharmaceutical research. This compound is essential for researchers and manufacturers in the fine chemical, agrochemical, and advanced material sectors who require high-purity, specialized intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, particularly where steric bulk is required to modulate biological activity or metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the pentamethylbenzyl moiety can enhance product efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized phosphine or N-heterocyclic carbene (NHC) ligands used in homogeneous catalysis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its ability to impart specific steric and electronic characteristics.
• Fine Chemical Production: Intermediate for dyes, pigments, and other performance chemicals requiring tailored aromatic structures.

Basic Information

Product Name	2,3,4,5,6-Pentamethylbenzyl Chloride
CAS No.	484-65-1
Molecular Formula	C₁₂H₁₇Cl
Molecular Weight	196.72 g/mol
Synonyms	(2,3,4,5,6-Pentamethylphenyl)methyl Chloride; Pentamethylbenzyl Chloride; 1-(Chloromethyl)-2,3,4,5,6-pentamethylbenzene; α-Chloropentamethyltoluene; Benzene, 1-(chloromethyl)-2,3,4,5,6-pentamethyl-; Chloromethylpentamethylbenzene
EINECS	207-614-6

Quality Control

Every batch of 2,3,4,5,6-Pentamethylbenzyl Chloride is produced and tested under a strict quality management system to ensure consistency and reliability for your synthetic processes. Our standard grade typically meets a purity specification of ≥97% (by GC or HPLC), but higher purity grades are available. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥97.0%
Melting Point	Contact for details
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.