Description

4-(Trifluoromethoxy)Chlorobenzene is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both a chlorobenzene core and a trifluoromethoxy substituent, makes it a critical intermediate for introducing specific physicochemical properties into target molecules. This compound is primarily sought after by the agrochemical and pharmaceutical industries for the development of novel active ingredients, where its unique fluorine-containing moiety can enhance metabolic stability, lipophilicity, and bioavailability.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of modern herbicides, insecticides, and fungicides, where the trifluoromethoxy group improves efficacy and environmental profile.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and inflammatory diseases.
• Liquid Crystal & OLED Material Synthesis: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modification: Employed to introduce fluorine into polymer chains, enhancing chemical resistance, thermal stability, and surface properties of specialty plastics and coatings.
• Cross-Coupling Reactions: The chlorine atom makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Organic Synthesis Reagent: A valuable reagent in academic and industrial R&D for constructing fluorinated analogs of biologically active compounds.

Basic Information

Product Name	4-(Trifluoromethoxy)Chlorobenzene
CAS No.	461-81-4
Molecular Formula	C7H4ClF3O
Molecular Weight	196.55 g/mol
Synonyms	1-Chloro-4-(trifluoromethoxy)benzene; p-Chlorophenyl trifluoromethyl ether; 4-Chlorophenyl trifluoromethyl ether; 4-Chloro-α,α,α-trifluoroanisole; 4-Chloro-1-(trifluoromethoxy)benzene; p-(Trifluoromethoxy)chlorobenzene; 4-Chlorophenyl trifluoromethylether
EINECS	207-320-5

Quality Control

Our 4-(Trifluoromethoxy)Chlorobenzene is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our production and quality processes are designed to meet the stringent requirements of GMP and ISO standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. Ensure the storage area is free from moisture and direct heat sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.