Description

3,3-Difluoropropan-1-ol is a versatile fluorinated alcohol building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the difluoromethylene group adjacent to the hydroxyl function, enabling precise molecular modifications. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors seeking to incorporate fluorine for enhanced biological activity or material properties.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitors and other bioactive molecules where fluorine substitution modulates metabolism and binding affinity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the difluoro group can improve lipophilicity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved dielectric anisotropy and thermal stability.
• Polymer Modification: Employed to introduce fluorine into polymer side chains, enhancing surface properties, chemical resistance, and reducing dielectric constant in specialty coatings and resins.
• Organic Synthesis Building Block: A valuable reagent for nucleophilic substitution reactions, esterifications, and as a precursor to corresponding aldehydes, acids, and halides in complex molecule construction.

Basic Information

Product Name	3,3-Difluoropropan-1-ol
CAS No.	461-52-9
Molecular Formula	C3H6F2O
Molecular Weight	96.08 g/mol
Synonyms	3,3-Difluoropropanol; 3,3-Difluoro-1-propanol; 1-Propanol, 3,3-difluoro-; 3,3-Difluoropropyl alcohol; DFPA; 461-52-9; 3,3-Difluoropropan-1-ol (IUPAC); 3,3-Difluoropropan-1-ol CAS 461-52-9
EINECS	207-321-3

Quality Control

Our 3,3-Difluoropropan-1-ol is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all critical parameters are provided and available upon request. We support compliance with REACH and other relevant global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong acids and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature: 2-8°C for extended stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.370 - 1.380
Density (20°C)	1.20 - 1.30 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.